IndraLab

Statements


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"m6A, m5C, m5U, s2U, and Psi modifications impeded stimulation of TLR7 and 8 (see XREF_FIG for structures)."

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"Meanwhile, the substitution of original nucleotides with m5C, 5-methyluridine (m5U), s2U, m6A, and ψ can prevent TLR7 and TLR8 activation, assisting in avoiding activation of the innate immune system and promoting protein translation efficiency (2, 105)."