IndraLab

Statements

STAMBP binds CHMP3 and VPS4A. 2 / 2
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"The MIM 1 sequence motif responsible for VPS4 interaction [ xref ] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
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"Furthermore the AMSH binding site overlaps with the VPS4 site on CHMP3 ( xref ) [ xref , xref ], consistent with the finding that AMSH CHMP3 and VPS4 binding are exclusive (data not shown)."
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