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YOD1 leads to the deubiquitination of NLRP3. 2 / 2

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"6A and S4D, E, YOD1 significantly reduced the ubiquitination of NLRP3, while ASC and Caspase-1 did not, suggesting that YOD1 inhibited NLRP3 inflammasome activation by cleaving NLRP3 ubiquitination."

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"However, compared with the control group, overexpression of Yod1 abrogated WT ubiquitination of NLRP3 (Fig. 6B), while knockout of Yod1 significantly enhanced them (Fig. 6C)."

38789414

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IndraLab

Statements

YOD1 leads to the deubiquitination of NLRP3. 2 / 2

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