IndraLab

Statements

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"As the s, P5091 is also an elective dual-inhibitor of USP7 and USP47 that can suppress CRC cell growth and induces their apoptosis in vitro (An et al., 2017)."
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"USP47 knockdown attenuated myocardial cell I/R injury by inhibiting apoptosis."
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"Notably, selective dual inhibitors of USP7 and USP47 have been synthesized and induced accumulation of p53 and apoptosis in human cancer cell lines [XREF_BIBR]."
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"The silencing of USP47 increases the rate of apoptosis and the cytotoxic effects induced by chemotherapeutic agents in several strains, including osteosarcoma and breast cancer cells."
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"In agreement with this result, we observed that silencing of USP47 augments the apoptosis of MCF-7 breast cancer cells, which are known to be resistant to inhibition of NF-kappaB."
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"Also, knockdown of USP47 induced CRC cell apoptosis ( Fig. S1D )."
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"Besides, numerous results demonstrated that knockdown of USP47 increased the percentage of apoptosis and inhibited cell proliferation, which were consistence with our study."
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"USP47 facilitated osteosarcoma cell invasion and migration, and suppressed apoptosis."
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"In cultured CRC cells, knockdown of USP47 increased pyroptosis and apoptosis induced by chemotherapeutic doxorubicin."
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"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
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"Knockdown of USP47 expression in human osteosarcoma U-2OS and SAOS-2 cells and breast cancer T47D, BT-20, and MCF7 cells significantly induced apoptosis and improved the sensitivity to chemotherapeutic drugs.Ubiquitin-specific peptidase 47 knockdown inhibited the proliferation of A549 lung cancer cells and PC3 prostate cancer cells by deubiquitinating β-catenin (Shi et al., 2015)."
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"Their findings also showed that USP47 knockdown sensitized NCI-N87 cells to camptothecin- or etoposide-induced apoptosis [66]."
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"USP47 facilitated osteosarcoma cell invasion and migration , and suppressed apoptosis ( 46 ) ."
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"Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines."
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"SMURF2 is negatively regulated by USP47, and USP47 depletion sensitizes colon cancer cells to 5-FU-treatment-induced apoptosis."
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