IndraLab

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IGF1 decreases the amount of IRS1. 10 / 12
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"In our present study, we found that IGF1 depletion inhibited the expression of IRS1, PI3K, and Akt and upregulated both the mRNA and protein expression of AMPK and FOXO; meanwhile, the expression of JNK significantly increased in the IGF1 suppression group, which is important upstream of IRS1."
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"Further study found that IGF1 could down-regulate the expression of IRS1 and IRS2 in the chondrocytes, implying that IRS1 and IRS2 play a major negative role in cell differentiation."
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"The reduced IRS-1 protein levels could have been mediated by insulin and IGF -1 resistance, since insulin and IGF-1 regulate IRS gene expression [XREF_BIBR - XREF_BIBR]."
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"In vivo studies also demonstrated that the direct application of IGF-I to the motoneurons in G93A-SOD1 mouse models activates the PI3K and Akt, p44/42 MAPK and downregulated IGF-IR and IRS-1 expression."
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"Indeed, extended IGF-I stimulation for 24 hrs modestly decreased IRS-1 levels in MCF-7 and shPTEN but not MCF-7 and shMM cells."
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"Regarding the upstream components of the pathway, the sources of significant variance detected by two-way ANOVA tests were due to similarly elevated levels of insulin receptors (Figure 5A), IGF-1 receptors (Figure 5D), and p/T IRS-1 (Figure 5I), and reduced expression of pY-Insulin receptors (Figure 5B), p/T Insulin (Figure 5C) and IGF-1 (Figure 5F) receptors, and IRS-1 (Figure 5G) in CS and ES relative to CC and/or EC."
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"We also showed, in this report, that IRS-1 protein level was decreased by IGF-I stimulation, leading to suppression of IGF-I signal activation."
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"Continuous intrathecal administration of IGF-I also decreased levels of IGF-IR and IRS-1, which are up-regulated in the transgenic mice compared to control mice."
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"High concentrations of IGF-I decreased levels of IGF-IR and IRS-1 and inhibited the expression and activation of PDGFRalpha."
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"The protein can be inhibited by the compound NT157 [25], which has two mechanisms of action: 1) reduce IGF1 signaling through dissociation of IRS1 from the IGF1 receptor, and 2) reduce levels of IRS1 by phosphorylation at serine sites that lead to proteosomal degradation [25]."
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