IndraLab

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IL10 increases the amount of TLR4. 12 / 18
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"Toll like receptor (TLR) 2 and TLR4 mRNA, as well as TLR4 surface expression, were significantly up-regulated by IL-10 in adherent cells."

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"Concomitantly, increases in irisin seem to shift macrophages phenotype action on adipose tissue from M1 (pro-inflammatory) toward M2 (anti-inflammatory), while decreasing the expression of TLR4, TNF-α[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Compared with the NC group, in the model group, the myocardial infarction was large; inflammatory cell infiltration was severe; apoptosis was enhanced; expression of TLR4, JAK2, and STAT3 was increased; and serum concentrations of IL-6, TNF-alpha, IL-10, and HMGB1 were significantly increased."

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"Testosterone reduces expression of TLR4, reduces synthesis of TNF, and increases BAFF, IL-10, IL-12 and TGF-β production from macrophages (88, 129, 270, 271)."

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"Binding sites for CREB have been identified in the IL-10 promoter, and mutation of the MSK phosphorylation site, Ser133, in CREB reduced TLR4 induced IL-10 transcription."

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"Compared with the normal group, the model group showed increased white blood cells, elevated IL-6 and TNF-α levels(P<0.01), lowered IL-10 level(P<0.01), up-regulated protein levels of TLR4, MyD88, p-p65/NF-κB p65, and p-p38 MAPK/p38 MAPK(P<0.01) and mRNA levels of TLR4 and MyD88(P<0.01) in the lung tissue."

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"Of note, we have demonstrated that IL-10 administration suppressed the expression of FcgammaRI and enhanced the expression of TLR4 and CR3, which in turn prevented the survival of E. coli K1 in MO XREF_BIBR."

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"Acupuncture obviously reversed the increase of TLR4, MyD88, TRAF6, NF-κB p65, TNF-α, and mRNA expression levels of TLR4 in the hippocampus, decreased IL-1β, and elevated IL-10 in serum."

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"In mice submitted to a CUMS model of depression, 8 weeks of treadmill exercise significantly improves hippocampal function, reducing levels of IL-1β, NF-kB, toll-like receptor 4 (TLR-4), myeloid differentiation factor 88 (MyD88) and TNF-α and increasing levels of IL-10 and the expression of miR-223 in this structure [173]."

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"We recruited 80 patients to measure the expression of HMGB1, IL-17, and IL-10; 55 patients were recruited to measure the expression of TLR2 and TLR4 in monocyte and CD1c+dendritic cells, and 30 volunteers were included as controls."

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"Preimplantation kidney biopsies from ECD (n=41) and SCD (n=39) were evaluated for real-time quantitative polymerase chain reaction (qPCR) gene expression using the TaqMan Gene Expression Array Plates system for genes TLR4, HMGB1, NFK-beta, MyD-88, INF-gamma, IL1-beta, TNF-alpha, CASP1, ICAM-1, IL-10, HO-1, HIF-1, MCP-1, TGF-beta, TRIF, TRAM, IRF-3, RIP1, INFbeta-1 and NLRP3."

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"Neutrophils produced a significant increase of IL-8, IL-1beta and TNF-alpha after 3, 6 and 24 h of H. pylori challenge, respectively, whereas IL-10 increased after 24 h. Helicobacter pylori challenge increased TLR2 and TLR4 expression; and antibodies against TLR2 and TLR4 diminished significantly the H. pylori induced production of IL-8 and IL-10."