IndraLab

Statements

Staurosporine inhibits JUN. 3 / 3
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"The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein."
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"As shown in Fig. 3, H-89 did not affect C2-ceramide-induced c-jun expression, whereas H-7 and staurosporine strongly inhibit c-jun induction by C2-ceramide."
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"Moreover, our preliminary data showed that TPA induced free radicals and c-jun were not suppressed by staurosporine (data not shown)."
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