IndraLab

Statements

USP22 activates Interferon. 4 / 4
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"However, USP13, USP19, and USP22 inhibit virus-induced IFN production by removing K27-linked polyubiquitin chains from STING (40, 81) or TRIF (90)."
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"In mechanism, USP22 enhances the stability of STAT1 via deubiquitination and promotes the activation of IFNγ stimulation in melanoma [ 43 ]."
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"18 Besides, USP22 in melanoma cells stabilizes STAT1 and promotes the interferon pathway, which improves the cytotoxic effects of CD8 T cells."
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"Increased USP22-dependent upregulation of IFN signaling in Caco-2 cells was also reflected in the elevated expression of the antiviral ISGs IRF9 and OAS3 (Fig. 6B)."
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