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USP2 activates JUP. 3 / 3
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"This effect is achieved through the activation of USP2, which enhances the stability of JUP protein via deubiquitination modification, subsequently blocking the Akt/β-catenin pathway (Fig. 8)."
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"Indeed, we found that the USP2 overexpression in cardiomyocytes enhanced the protein stability of JUP, which is a novel interaction that has been reported before."
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"Collectively, we hypothesized that Mycn possibly regulates USP2 transcription, which modulates JUP protein stability and the Akt/β-catenin signaling to affect cardiac hypertrophy progression."
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