IndraLab

Statements

UCHL1 inhibits mTORC1. 7 / 9
| 1 1 5
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"The inhibition of mTORC1 by rapamycin increased UCHL1 protein levels by AS Uchl implied a mechanism of antisense lncRNAs in the control of cellular stress signaling pathways and their roles in neurodegenerative diseases [57]."
32959025
reach
"For example, DDB1 and CUL4 mediated polyubiquitination of Raptor enhances the stability and activity of the mTORC1 complex, which can be antagonized by the ubiquitin hydrolase UCH-L1 [XREF_BIBR, XREF_BIBR]."
| PMC
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"We find that UCH-L1 impairs mTORC1 activity toward S6 kinase and 4EBP1 while increasing mTORC2 activity toward Akt."
23297343
trips
"Here, we show that the ubiquitin hydrolase UCH-L1 regulates the balance of mTOR signaling by disrupting mTORC1."
23297343
reach
"The inhibition of mTORC1 by rapamycin increased UCHL1 protein levels by AS Uchl implied a mechanism of antisense lncRNAs in the control of cellular stress signaling pathways and their roles in neurodegenerative diseases [XREF_BIBR]."
32959025
eidos
"Consistently , in C2C12 cells , UCHL1 knockdown increased the myotube size , enhanced mTORC1 activity , and reduced mTORC2 activities as compared with control cells ."
31356902
reach
"Consistently, in C2C12 cells, UCHL1 knockdown increased the myotube size, enhanced mTORC1 activity, and reduced mTORC2 activities as compared with control cells."
31356902