IndraLab

Statements

USP18 inhibits Fibrosis. 3 / 3
| 3
reach
"Injection of USP18 lentivirus into the portal vein of a CCl 4 -induced liver fibrosis mouse model confirmed that overexpression of USP18 can significantly reduce the degree of liver fibrosis."
39236989
reach
"In brief, the authors observed that cardiomyocyte-specific overexpression of USP18 attenuated myocardial hypertrophy, fibrosis, ventricular dilatation, and ejection fraction decline induced by aortic banding, whereas USP18 knockout exacerbated remodeling (59)."
38665231
reach
"Experiments performed in transgenic mice demonstrated that the increased USP18 expression in cardiomyocytes upon an increased afterload attenuated the cardiomyocyte hypertrophy and myocardial fibrosis, resulting in the delayed development of heart failure."
38791035