IndraLab

Statements

Thioridazine inhibits KCNH5. 3 / 3
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"Additionally, thioridazine has been shown to inhibit EAG2 channels, preventing the cell volume changes required for tumor cell migration and invasion [6,53]."
40150732
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"It thus appears that thioridazine block of EAG2 potassium channel not only compromises its volume regulation crucial for human MB cell proliferation and motility, but also reduces the activity of KCNT2 potassium channel as a downstream effector of EAG2 channel activity (XREF_SUPPLEMENTARY)."
26258683
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"Thioridazine blocks EAG2 and reduces MB tumorigenicity."
26258683