IndraLab

Statements

Paroxetine inhibits KCNH2. 5 / 5
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"Paroxetine inhibited the peak tail currents of the HERG channel in a concentration dependent manner, with an IC50 value of 0.45 microM and a Hill coefficient of 0.85."
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"Although the reasons for this rare adverse event are not clear, we postulated that HERG channel blockade by paroxetine, some genetic changes, or autonomic nervous factors may have been involved in this rare event induced by paroxetine."
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"SSRIs can induce QTc prolongation via blockade of the delayed potassium rectifier current (IKr).7 Paroxetine blocks HERG channels that encode IKr in vitro.8 Niemeijer etal.9 reviewed categories of genetic factors related to drug induced QTc prolongation."
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"Blockade of HERG human K+ channels by the antidepressant drug paroxetine."
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"These results suggest that paroxetine blocks the HERG channels by binding to these channels in the open and inactivated states."
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