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Iron atom activates KCNH2. 4 / 4
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"In any case, we can conclude that iron depletion downregulates Erg1 abundance even in the presence of terbinafine, contributing to its susceptibility."
35837730
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"Here, we show that ROX1 deletion leads to an increase in ERG1 transcript and protein levels under both iron‐sufficient and iron‐deficiency conditions (Figure 4), strongly suggesting that Rox1 also limits ERG1 gene expression when iron bioavailability decreases."
35837730
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"Later, two iron and copper repressible promoters P and P , respectively are characterized and used to repress the ERG1 gene in S. cerevisiae towards squalene bioproduction."
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"These results suggested that histidines in the S 5 -S 6 linker are crucial players in iron dependent ROS production modulating KCNH2 K + channel function."
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