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USP4 increases the amount of ACE2. 2 / 2

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"The authors proposed that USP4 overexpression enhances ACE2 protein levels [134]; nevertheless, the supporting data are lacking."

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"To verify whether USP4 may regulate ACE2 expression through deubiquitination, we performed Co-IP experiments, which showed that USP4 could interact with ACE2 and that overexpression of USP4 upregulated ACE2 expression (Fig. 5V)."

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USP4 increases the amount of ACE2. 2 / 2

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