IndraLab

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VCPIP1 activates STX5. 2 / 2

| 2

reach

"As shown in XREF_FIG G, VCIP135 partially prevented alpha-SNAP binding to GST-syn5DeltaTM, suggesting that VCIP135 directs syntaxin5 to p97 and p47 but not to alpha-SNAP and NSF."

12473691

➶

reach

"In mitosis, VCIP135 is phosphorylated at S130 by Cdk1 and thus is inactivated, allowing syntaxin 5 to be ubiquitinated by HACE1; in telophase, VCIP135 is dephosphorylated and reactivated, removing ubiquitin from syntaxin 5 to allow p97 mediated membrane fusion."

31435807

INDRA sources:

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IndraLab

Statements

VCPIP1 activates STX5. 2 / 2

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