IndraLab

Statements

YOD1 leads to the deubiquitination of TP53. 3 / 3
| 3
reach
"As expected, the knockdown of YOD1 increased p53 ubiquitination, while overexpression of the mutant showed no effect (Fig. 3E, F and Supplementary Fig. 5B), indicating that the protein level of catalytically active YOD1 is responsible for the changes in p53 ubiquitination."
37454155
reach
"Interestingly, we found that YOD1 transfection inhibited the p53-MDM2 interaction (Fig. 3I) and consequently MDM2-induced p53 ubiquitination (Fig. 3J)."
37454155
reach
"Presumably, this may lead to the deubiquitination of p53 by YOD1."
37454155