IndraLab

Statements

USP14 inhibits NFkappaB. 7 / 8
| 7
reach
"Furthermore, USP14 was also found to inhibit the RIG-I-triggered NF-kappaB activation by deubiquitinating K63 linked RIG-I."
33360745
reach
"These results suggest that USP14 specifically enhanced NLRC5 mediated inhibition of NF-kappaB activation through the inhibition of NLRC5 ubiquitination via its DUB activity."
29326710
reach
"Because USP14 specifically enhanced NLRC5 mediated inhibition of NF-kappaB activation, we reasoned that USP14 deficiency would result in the accumulation of ubiquitinated NLRC5 and increased NF-kappaB activation under physiological conditions."
26620909
reach
"We found that overexpression of USP14 in 293/TLR4 cells suppressed NF-kappaB activity through TLR4 stimulation."
29326710
reach
"In this study, we aimed to clarify the role of the USP14-NLRC5 pathway in wear particle induced osteolysis in vitro and in vivo We found that NLRC5 or USP14 overexpression inhibits titanium particle induced proinflammatory tumor necrosis factor alpha (TNF-alpha) production and NF-kappaB pathway activation, and also decreases M1 macrophage polarization and PI3K and AKT pathway activation."
32273344
reach
"Next, we tested whether USP14 also enhanced NLRC5 mediated inhibition of TRAF2/6 independent noncanonical NF-kappaB signaling."
26620909
reach
"These results suggest that USP14 inhibits NF-kappaB signaling in an NLRC5 dependent manner."
26620909