IndraLab

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USP14 inhibits NFkappaB. 9 / 10
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"Next, we tested whether USP14 also enhanced NLRC5 mediated inhibition of TRAF2/6 independent noncanonical NF-kappaB signaling."
26620909
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"Furthermore, USP14 was also found to inhibit the RIG-I-triggered NF-kappaB activation by deubiquitinating K63 linked RIG-I."
33360745
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"These results suggest that USP14 inhibits NF-kappaB signaling in an NLRC5 dependent manner."
26620909
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"In this study, we aimed to clarify the role of the USP14-NLRC5 pathway in wear particle induced osteolysis in vitro and in vivo We found that NLRC5 or USP14 overexpression inhibits titanium particle induced proinflammatory tumor necrosis factor alpha (TNF-alpha) production and NF-kappaB pathway activation, and also decreases M1 macrophage polarization and PI3K and AKT pathway activation."
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"Because USP14 specifically enhanced NLRC5 mediated inhibition of NF-kappaB activation, we reasoned that USP14 deficiency would result in the accumulation of ubiquitinated NLRC5 and increased NF-kappaB activation under physiological conditions."
26620909
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"In the present study, we utilized a rat model of type 2 diabetes mellitus induced by HFD and STZ and determined whether TGT could suppress the activation of TLR4 and NF-kappaB pathways and thereby attenuate renal tubulointerstitial injury."
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"In addition, USP14 mediates the degradation of IκBɑ(NF-kB inhibitor protein) to activate NF-kB."
35430212
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"These results suggest that USP14 specifically enhanced NLRC5 mediated inhibition of NF-kappaB activation through the inhibition of NLRC5 ubiquitination via its DUB activity."
29326710
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"We found that overexpression of USP14 in 293/TLR4 cells suppressed NF-kappaB activity through TLR4 stimulation."
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