IndraLab

Statements

BAP1 binds EED. 9 / 9
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"The molecular functions of ASXL1 are still incompletely elucidated: ASXL1 forms the polycomb-repressive deubiquitinase (PR-DUB) complex with the H2AK119 deubiquitinase BAP1 [73] , which is a myeloid t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24507812
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"Deubiquitination of nucleosomal H2A is performed using a minimal Polycomb Repressive Deubiquitinase (PR-DUB) complex formed by the human deubiquitinase BAP1 and the DEUBiquitinase ADaptor (DEUBAD) domain of its co-factor ASXL2."
31403616
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"In this study, we have identified a critical link between Polycomb repressive deubiquitinase-BAP1 (PR-DUB) complex and BRD4, which is bridged by the physical interaction between additional sex combs-like protein 3 (ASXL3) in SCLC."
32669118
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"Numerous studies have demonstrated that truncated ASXL1 mutants, including the ASXL1 fragment containing amino acids 1–587, promote myeloid transformation by forming a stable polycomb-repressive deubiquitinase (PR-DUB) complex with BAP1, enhancing BAP1 deubiquitinase (DUB) activity [ xref , xref , xref ]."
38791157
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"The interaction with BRCA1 and BARD1 form a tumor suppressor heterodimeric complex. [ xref ] BAP1 regulates cell proliferation and interacts with histone-modifying complexes during cell division. [ xref , xref ] BAP1 also forms the Polycomb group repressive deubiquitinase complex (PR-DUB) through interaction with ASXL1, which is involved several developmental processes. [ xref ] Because of this functional complexity, BAP1 germline mutations predispose individuals to the aggressive tumor phenotypes."
25830670
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"BAP1 interacts with ASXL family members to form the polycomb group repressive deubiquitinase complex involved in stem cell pluripotency and other developmental processes ( xref , xref )."
29284740
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"ASXL1 also forms another chromatin modifying complex, the polycomb-repressive deubiquitinase (PR-DUB) complex with the H2AK119 deubiquitinase BAP1 [46] ."
24507815
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"BAP1 forms the polycomb group repressive deubiquitinase complex (PR-DUB) with ASXL1/2 in the nucleus."
40506895
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"BAP1 and its related proteins form the polycomb inhibitory deubiquitinase (PR-DUB) complex, whose main role is to remove mono-ubiquitin from ubiquitinated histone 2A at lysine 119 (H2Aub)."
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