IndraLab

Statements

Acetophenone inhibits KCNH2. 3 / 3
| 3
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"In both substituted azabenzimidazole derivatives, α-substitution in the phenyl ring increased hERG inhibitory activity as observed in compounds 10 (5-methyl) and 12 (6-chloro, Table 1)."
38628794
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"Replacement of the phenyl ring with a 4-pyridyl ring system at the 2-amino position improved solubility (830muM) and reduced the hERG liability (IC 50 85muM)."
25823686
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"Introduction of a sulfonamide and two halogen substituents at the phenyl ring (97) turned out to decrease hERG affinity and retained antiviral activity."
| PMC