IndraLab

Statements

Ergosterol decreases the amount of KCNH2. 4 / 4
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"Inhibition of ergosterol biosynthesis with terbinafine increases the expression of ERG1 in a concentration dependent manner to a maximum of sevenfold."
11179957
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"Inhibition of ergosterol biosynthesis with the antifungal drug terbinafine at squalene epoxidase step can trigger increased level of ERG1 expression in a concentration dependent manner to a maximum of sevenfold [XREF_BIBR]."
25889168
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"ERG 1 expression is known to be regulated by cellular ergosterol levels, as inhibition of ergosterol production induces ERG 1 expression through a novel regulatory DNA sequence element in the ERG 1 pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21075079
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"A mechanism of feedback inhibition of ERG1 expression by cytoplasmic ergosterol was previously described (Leber et al., 2001; Garaiova et al., 2014) and this regulation may be the explanation for higher squalene accumulation in the pdr18Delta mutant."
32985771