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CYLD activates cisplatin. 3 / 3
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"Furthermore, the results indicated that CRAL mainly resided in the cytoplasm and could sponge endogenous miR-505 to upregulate cylindromatosis (CYLD) expression, which further suppressed AKT activation and led to an increase in the sensitivity of gastric cancer cells to cisplatin in vitro and in preclinical models."
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"40 In the same publication, suppression of CYLD by CYLD‐specific siRNA can reverse the cisplatin‐resistant phenotype, indicating that CYLD is one of the major proteins that facilitate oral cancer resistance."
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"Cisplatin resistance is also caused by CYLD (CYLD lysine 63 deubiquitinase) downregulation, which triggers the reduction of intracellular CDDP accumulation and the suppression of cell death via NF-κB hyperactivation [57]."
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