IndraLab

Statements

CALM bound to KCNQ2 activates KCNQ2. 5 / 5
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"Disruption of calmodulin binding to KCNQ2 also impairs enrichment of heteromeric KCNQ2 and KCNQ3 channels at the axonal surface by blocking their trafficking from the endoplasmic reticulum to the axon."
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"To test whether CaM binding to KCNQ2 promotes trafficking of HA-KCNQ3 and KCNQ2 channels from the ER to the axon, we performed pulse-chase experiments after removal of BFA."
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"Disruption of CaM binding to KCNQ2 impairs trafficking of HA-KCNQ3 and KCNQ2 channels from the ER to the axon."
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"Disruption of CaM binding to KCNQ2 inhibits enrichment of HA-KCNQ3 and KCNQ2 channels at the axonal surface."
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"These results together indicate that disruption of CaM interaction with KCNQ2 by the A343D mutation impairs the trafficking of HA-KCNQ3 and KCNQ2 channels from the ER to the axon."
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