IndraLab

Statements

USP7 inhibits CCDC6. 3 / 3
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"Meanwhile, CCDC6 was reported to be one of the substrates of USP7, which can prevent CCDC6 from ubiquitination and stabilize it."
33967786
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"A panel of HGSOC cell lines (either BRCA-wild type or mutant) were treated with PARPi after CCDC6 was attenuated by silencing or by inhibiting USP7, a CCDC6-deubiquitinating enzyme, and the effects on cell survival were assessed."
35964058
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"The inhibition of USP7, using P5091, was assayed in vitro to accelerate CCDC6 turnover in order to sensitize the neuroendocrine cancer cells to PARP-inhibitors, alone or in association with cisplatinum."
27372520