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USP10 deubiquitinates NLRP7. 8 / 8
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"For example, overexpression of USP10 stabilizes Krüppel-like factor 4 and suppresses lung tumorigenesis 25, whereas USP10 deubiquitinates NLRP7 and promotes colorectal cancer progression by activating the immunosuppressive state 26."
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"Collectively, the present results indicated that NLRP7 in CRC cells interacts with and is deubiquitinated by USP10, resulting in increased NLRP7 protein stability."
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"NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in CRC (28)."
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"<span class="match term1">NLRP7</span> deubiquitination by <span class="match term0">USP10</span> promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer"
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"USP10 deubiquitinates NLRP7 protein in CRC, stabilizing NLRP7 and prompting M2 macrophage polarization via NF-κβ-dependent secretion of monocyte chemoattractant protein-1 (MCP-1)."
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"NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer."
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"NLRP7 deubiquitination by USP10 promotes tumor progression and tumor associated macrophage polarization in colorectal cancer."
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"Co-IP experiments showed that USP10 knockdown increased the ubiquitination of NLRP7 in HCT116 cells."
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