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IRX5 inhibits KCND2. 6 / 6
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"These results demonstrate that Irx5 can repress Kcnd2 , and this is likely to occur via interaction with mBop and the recruitment of HDACs, although other proteins may also be involved in the repressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, Irx5 may act to repress Kcnd2 in endocardial myocytes."
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"We conclude that Irx5 can dose-dependently repress the activity of the Kcnd2 promoter and hypothesized that Irx5 repressor activity in cardiac myocytes requires a cardiac-specific corepressor protein.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Zhao et al. [ 48 •• ] determined in vivo miR-1-2 targets, including the cardiac transcription factor, Irx5, which represses the potassium channel, Kcnd2 [ 13 ]."
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"Consistent with this hypothesis, Irx5 dose-dependently inhibited the activity of a Kcnd2 promoter construct in cardiac myocytes."
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"Zhao et al. [XREF_BIBR] determined in vivo miR-1-2 targets, including the cardiac transcription factor, Irx5, which represses KCND2, a potassium channel subunit (Kv4.2) responsible for transient outward K + current (I to) [XREF_BIBR, XREF_BIBR]."
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