IndraLab

Statements

USP25 activates cell growth. 10 / 10
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"USP21 stabilizes BRCA2 in patient derived HCC tumor cell lines, protects from DNA damage and promotes tumor cell growth in a BRCA2 dependent manner."
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"We identify that knockdown of USP21 inhibits cell proliferation, and overexpression of USP21 promotes cell growth."
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"Thus far, a study proved that USP21 can accelerate cell growth, invasion, and stemness of renal cell carcinoma."
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"Overexpression of USP21 increase the cell growth, invasion and cancer stem cell percentage of 786-O and A-704 cells."
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"Amplification of USP21 deubiquitinase promotes pancreatic cancer cell growth and stemness via Wnt and beta-catenin signaling [XREF_BIBR]."
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"Here, we have shown that USP21 over-expression promotes HCC cell growth, cell cycle progression and in vivo tumorigenesis, while knockdown of USP21 inhibits these processes."
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"Second, USP25 can promote cell growth and tumor metastasis."
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"Plate formation and transwell assays revealed that USP21 -induced enhancement of cell growth, migration, and invasion in KYSE-150 and Eca-109 cells was obviously abolished by G3BP1 depletion (Fig. 4B–D, Fig. S8B–D)."
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"USP21 deubiquitinates and stabilizes BRCA2, promotes HR efficiency, and enhances homologous recombination efficiency and tumor cell growth."
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"Liu et al. [29] also reported that FGD5-AS1 could promote OSCC progression, and they confirmed via luciferase reported assays that FGD5-AS1 sponges miR-520b and restores the expression of USP21, which could promote OSCC cell growth and migration and inhibit OSCC cell apoptosis [29]."
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