IndraLab

Statements


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"Overexpression of USP21 increase the cell growth, invasion and cancer stem cell percentage of 786-O and A-704 cells."

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"We identify that knockdown of USP21 inhibits cell proliferation, and overexpression of USP21 promotes cell growth."

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"Amplification of USP21 deubiquitinase promotes pancreatic cancer cell growth and stemness via Wnt and beta-catenin signaling [XREF_BIBR]."

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"USP21 deubiquitinates and stabilizes BRCA2, promotes HR efficiency, and enhances homologous recombination efficiency and tumor cell growth."

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"USP21 stabilizes BRCA2 in patient derived HCC tumor cell lines, protects from DNA damage and promotes tumor cell growth in a BRCA2 dependent manner."

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"Thus far, a study proved that USP21 can accelerate cell growth, invasion, and stemness of renal cell carcinoma."

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"Here, we have shown that USP21 over-expression promotes HCC cell growth, cell cycle progression and in vivo tumorigenesis, while knockdown of USP21 inhibits these processes."