IndraLab
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reach
"Immunostaining and proteomics analysis indicate that the USP12/46-WDRs complex-mediated Itgb1 deubiquitination occurs at endosomes, as neither our immunostainings nor previous studies on the adhesome composition found the complex in integrin adhesion sites.The genetic as well as poximitome screenings neither identified USP9X nor USP10, which have been reported to deubiquitinate α5β1 integrins (Gillespie et al, 2017; Kharitidi et al, 2015)."