IndraLab

Statements

BAP1 activates KLF5. 7 / 7
| 7
reach
"To test whether BAP1 can antagonize E3 ligase mediated KLF5 degradation, we transfected KLF5 E3 ligases and BAP1 into HEK293FT cells and detected the KLF5 protein levels."
26419610
reach
"To further confirm whether BAP1 increases KLF5 protein stability, we transfected two different siRNAs targeting different regions of BAP1 into MCF10A and breast cancer cell lines (HCC1806 and HCC1937)."
26419610
reach
"Taken together, these results demonstrate that BAP1 promotes HCC1806 breast cancer tumorigenesis partially by stabilizing KLF5."
26419610
reach
"However, BAP1 positively regulates KLF5 at the protein level."
26419610
reach
"Collectively, these results suggest that BAP1 is a specific DUB for KLF5 and that BAP1 increases KLF5 protein stability in a DUB activity dependent manner."
26419610
reach
"These results indicate that BAP1 promotes KLF5 positive breast cell proliferation in vitro."
26419610
reach
"Besides, BAP1 promoted KLF5 mediated growth of melanoma in vivo."
33516665