IndraLab

Statements

BAP1 activates KLF5. 8 / 8
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"However, BAP1 positively regulates KLF5 at the protein level."
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"For example, one study showed that BAP1 promotes the development of breast cancer by enhancing the stability of the transcription factor KLF5 (30)."
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"To further confirm whether BAP1 increases KLF5 protein stability, we transfected two different siRNAs targeting different regions of BAP1 into MCF10A and breast cancer cell lines (HCC1806 and HCC1937)."
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"To test whether BAP1 can antagonize E3 ligase mediated KLF5 degradation, we transfected KLF5 E3 ligases and BAP1 into HEK293FT cells and detected the KLF5 protein levels."
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"The results showed that knocked down BAP1 rescued the promoting effect of overexpressed KLF5 on volume and weight of tumor in nude mice ( Fig. 5 E)."
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"Collectively, these results suggest that BAP1 is a specific DUB for KLF5 and that BAP1 increases KLF5 protein stability in a DUB activity dependent manner."
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"These results indicate that BAP1 promotes KLF5 positive breast cell proliferation in vitro."
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"Taken together, these results demonstrate that BAP1 promotes HCC1806 breast cancer tumorigenesis partially by stabilizing KLF5."
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