IndraLab

Statements

USP15 activates TNF. 4 / 4
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"In addition, USP15 increases TNF-α− or IL-Iβ-induced NF-κB activity, which results in enhanced inflammatory responses by stabilizing the TGF-β activated kinase 1 binding proteins TAB2/3 ."
37394587
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"Overexpression of USP15 potentiated TNFalpha- or IL-1beta-triggered NF-kappaB activation and downstream genes transcription, whereas knockdown of USP15 had opposite effects."
31903660
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"Mechanistically, we find that USP15 functions in a haploinsufficient manner and that loss of USP15 or SCAF1 leads to reduced inflammatory TNFalpha, TGF-beta and IL6 responses and increased sensitivity to PARP inhibition and Gemcitabine."
38902237
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"Collectively, USP15 positively regulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by distinct mechanisms, which reflects the potential nonredundant roles of TAB2 and TAB3."
33469458