IndraLab

Statements

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"Arsenic interferes with the formation of hERG and chaperone complexes and inhibits hERG maturation causing ECG abnormalities."
16050262
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"Examples of this are β -adrenergic receptor stimulation which could be expected to increase heart rate and force of contraction, adenosine receptors α2A activity where stimulatory binding might be expected to decrease blood pressure, and blocking or antagonism of the hERG potassium channel that would prolong the ECG QT interval providing an opportunity for arrhythmia."
38590785
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"Dysfunction of the ion channel conducting I , the human ether-à-go-go-related gene (hERG) channel, can cause QT interval prolongation on an ECG."
38328302
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"TABLE 1: Summary of the main structure acquisition and molecular dynamics simulation results mentioned in the paper.FIGURE 1: Prolonged QT interval on ECG caused by hERG channel dysfunction."
34168566
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"Terfenadine is an antihistamine compound that also blocks the hERG channel Terfenadine is classified as a compound with intermediate risk to cause QT prolongation of the human ECG."
29061979