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USP28 deubiquitinates CHEK2. 2 / 3
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"However, it must be noted that USP28 can also deubiquitinate and stabilise other substrates not known to be associated with Fbw7, including Claspin [92] , Chk2 [93] , and LSD1 [94] , which could also [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP28 also modulates the DNA damage response (DDR) in cancer cells by deubiquitinating and stabilising the checkpoint kinase 2 (CHK2), the TP53-binding protein 1 (TP53BP1) and Claspin (CLSPN) [6, 7], thereby preventing apoptosis but establishing cell cycle arrest to facilitate DNA repair [8]."
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