IndraLab

Statements

USP22 increases the amount of MDM4. 3 / 3
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"Additionally, USP22 silencing downregulates MDMX protein expression and activates the p53 pathway."
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"In addition, similar to our in vitro findings, USP22 silencing led to a decreased level of MDMX and increased levels of p53 pathway proteins in xenograft tumor tissues (XREF_FIG C)."
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"Interestingly, we found that in A549 and NCI-H460 cells, USP22 silencing, while activating the p53 pathway, decreased MDMX protein expression (XREF_FIG C), which was confirmed with immunofluorescence (IF) analysis (XREF_FIG D)."
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