IndraLab

Statements

KCNE proteins activates KCNQ1. 7 / 7
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"The mechanisms by which KCNE proteins modulate KCNQ1 channel activity are still being debated."
17698596
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"The observation that multiple KCNE proteins can co-associate with and modulate KCNQ1 channels to produce biochemically diverse channel complexes has important implications for understanding K (V) channel regulation in human physiology."
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"KCNE proteins target different parts of the KCNQ1 channel, and this may be the reason why the modulations by KCNE proteins are various."
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"Although the physiological context for the interaction of KCNE1 with KCNQ1 is generally appreciated, KCNQ1 may also be modulated by other KCNE proteins in vivo.Different KCNE proteins can modulate KCN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These accumulated data support the idea that KCNE proteins interact with the VSDs of KCNQ1 and modulate the gating of the KCNQ1 channel."
25603957
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"The mechanisms by which KCNE proteins modulate KCNQ1 channels have long been studied and discussed; however, it is not well understood how different KCNE proteins exert considerably different effects on KCNQ1 channels."
22042987
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"KCNQ1 channel modulation by KCNE proteins via the voltage sensing domain."
25603957