IndraLab

Statements

P5091 activates Neoplasms. 6 / 6
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"The USP7 inhibitor P5091 has been demonstrated to effectively inhibit Wnt signaling and tumor growth, underscoring the pivotal role of USP7 in this context [28]."
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"For example, P5091 was able to induce apoptosis in non-neuroendocrine lung (L-NEC) tumor while P22077 reactivated p53 and induced apoptosis in human neuroblastoma (NB) and overcame cellular chemoresis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"When evaluated in mice with Lewis lung carcinoma, USP7 inhibitor P5091 slowed tumor growth and promoted the infiltration of M1 macrophages and IFN-γ-expressing CD8+ T cells."
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"For p53-deficient NSCLC, combination treatment with melatonin and the USP7 inhibitor P5091 could significantly inhibit tumor growth."
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"Administration of USP7 inhibitor P5091 (25 mg/kg) has been found to decrease the growth rate of tumor in vivo."
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"Furthermore, P5091 treatment caused FOXP3 loss in Treg cells decreased the proportion of Treg cells in tumor bearing mice."
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