IndraLab

Statements

STAT3 binds YOD1. 8 / 8
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"Inhibition of STAT3 abolished the cardioprotective effects of YOD1CKO in Ang II–infused mice, validating the YOD1-STAT3 axis in regulating cardiac hypertrophy."
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"YOD1 directly interacts with STAT3."
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"This study clarifies the role of YOD1 and introduces a previously unidentified YOD1-STAT3 axis in regulating pathological cardiac hypertrophy, providing valuable insights for drug development targeting this condition."
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"We confirmed the interaction between endogenous YOD1 and STAT3 in Ang II–induced mouse cardiac tissue ( xref )."
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"Exogenous YOD1 and STAT3 interaction was also observed in NIH 3T3 cells transfected with these two plasmids ( xref )."
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"Therefore, selecting YOD1 as an intervention on the YOD1-STAT3 axis can specifically inhibit STAT3 in pathological hypertrophic hearts, with less impacts on other tissues or cells."
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"These outcomes indicate that the YOD1-STAT3 axis plays a significant role in regulating pathological cardiac remodeling induced by Ang II."
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"To further investigate the specific regions in the YOD1-STAT3 interaction, plasmids containing various YOD1 mutants were constructed ( xref )."
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