IndraLab

Statements

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"The natural flavonoid cardamonin (CAR), a specific USP18 agonist, significantly improves cardiac function in TAC mice by enhancing USP18-mediated anti-hypertrophic effects, as evidenced by increased ejection fraction (EF%), reduced B-type natriuretic peptide (BNP) levels, and attenuated myocardial inflammation/fibrosis [157]."
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"Silencing of USP18 causes an increase in cell-associated ICAM-1, and VCAM-1 and in IL-6 secretion, as well as attenuation of inflammation by blocking the NFB pathway, according to Auclair et al. [40]."
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"Knockdown of USP18 enhances NF-kappaB activation as well as the inflammatory response."
26240016
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"We further confirm the alleviating effect of USP18 on LPS-triggered inflammation in vivo."
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"Although distinct reductions in adaptive immunity-related genes were observed, no differences were observed in the mRNA levels of the more general inflammatory cytokines C-C motif chemokine ligand 2 (Ccl2) and C-C motif chemokine ligand 3 (Ccl3) or ubiquitin-specific peptidase 18 (Usp18), which mediates the regulation of the inflammatory response to type 1 interferon (Fig. 3D)."
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