IndraLab

Statements

Diltiazem inhibits KCNH2. 2 / 2
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"In our experiments, verapamil caused high-affinity block of HERG current (IC50 = 143.0 nmol/L), a value close to those reported for verapamil block of L-type Ca2+ channels, whereas diltiazem weakly blocked HERG current (IC50 = 17.3 micromol/L), and nifedipine did not block HERG current."
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"XREF_BIBR reported for verapamil caused high-affinity block of KCNH2 channel current is close to its block of L-type Ca2+ channels ', whereas diltiazem only weakly suppresses KCNH2 current, and nifedipine has no effect."
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