IndraLab

Statements

reach
"We identified that nuclear USP18 diminishes binding of IFN regulated transcription factors to their corresponding DNA motifs in cooperation with NF-κB. Consequently, the suppression of USP18 not only enhances the expression of canonical IFN-stimulated genes (ISGs) but also activates a set of atypical ISGs and NF-κB target genes that induce cancer pyroptosis."
38799433
reach
"Knockdown of USP18 represses the transcription factor PML and RARalpha and inhibits growth of acute promyelocytic leukaemia [24]."
28709980
reach
"Nuclear USP18 cooperates with NF-κB to reduce the binding of IFN-regulated transcription factors to their corresponding DNA motifs."
38675828
reach
"Silencing USP18 prolongs the phosphorylated state of signal transducer and activator of transcription 1 (STAT1) and enhances the expression of ISGs in response to IFN-alpha [XREF_BIBR]."
25798824
reach
"Our genome wide analyses reveal that nuclear USP18 diminishes binding of IFN-regulated transcription factors to their corresponding DNA motifs in cooperation with NF-κB."
36646704