IndraLab

Statements


CTNNB1 activates KCNQ1. 3 / 3
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"Beta-catenin has been shown to interact with and/or modulate the activity of large-conductance Ca 2+ -activated K + channels XREF_BIBR, kainate receptors XREF_BIBR, Kv1.5 K + channels XREF_BIBR and KCNQ1 and KCNE1 K + channels XREF_BIBR."

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"Confocal microscopy revealed that beta-catenin enhanced the KCNE1 and KCNQ1 protein abundance in the cell membrane."

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"In conclusion, beta-catenin enhances I (Ks) by increasing the KCNE1 and KCNQ1 protein abundance in the cell membrane, an effect requiring vesicle insertion into the cell membrane."