IndraLab

Statements

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"To this end, we investigated whether UCHL1 regulated proinflammatory cytokines induced MSC apoptosis."
29686406
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"These data suggest that UCHL1 inhibition suppresses MSC apoptosis induced by proinflammatory cytokines via upregulation of Bcl-2."
29686406
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"Interestingly, an induced UCHL1 expression was also demonstrated in multipotent mesenchymal stromal cells (MSCs) upon stimulation with proinflammatory cytokines IFN-gamma plus TNF-alpha, and negatively regulated the immunosuppressive capacity and survival of MSC."
33585209
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"The results suggest that the proinflammatory cytokines upregulate UCHL1, which in turn promotes MSC apoptosis via Bcl-2-regulated activation of caspase 3."
29686406