IndraLab

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"Based on the results of cell clone formation assays and CCK-8 assays, overexpression of USP45 significantly promoted the proliferation of KYSE140 and KYSE410 cells (Fig. 1B, C), whereas knockdown of USP45 inhibited cell proliferation (Fig. 1D, E)."
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"USP45 Promotes Cancer Proliferation, Stemness and Drug Resistance."
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"In addition, the colony formation and proliferation of SiHa cells were significantly increased by USP45 overexpression (Figure 3D,E)."
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"In summary, we demonstrated that USP45 overexpression promoted cancer proliferation, stemness, drug resistance, and transformation of SiHa cells into CSC-like cells."
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"In the present study, we demonstrated that the expression level of USP45 in the majority types of tumors was positively correlated with the tumor stemness index, suggesting that upregulation of USP45 may promote the proliferation and metastasis of tumor cells."
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