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USP45 deubiquitinates SPDL1. 2 / 2

1 | 1

reach

"USP45 was found to promote cell migration by catalyzing the deubiquitination of SPDL1 protein and upregulating its protein expression level (Conte et al., 2018)."

35836933

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signor

"Spindly is mono-ubiquitylated and this ubiquitin can be removed by active USP45. K48 ubiquitylated complex that interacts with Spindly is also de-ubiquitylated by USP45. In the absence of USP45 catalytic activity, interaction is abolished and cell migration is affected similarly to the phenotype described for lack of Spindly."

30258100

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IndraLab

Statements

USP45 deubiquitinates SPDL1. 2 / 2

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