IndraLab

Statements

Modified COPS6 increases the amount of MYC. 2 / 2
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reach
"Overexpression of CSN6 increased the mRNA levels of Myc transcriptional targets (CDC25A, cyclin D1, and Tert) and decreased the mRNA levels of Myc transcriptionally repressed genes (p27Kip1, CDKN2B, and p21Cip1), while loss of CSN6 reversed the expression of these Myc target genes."
25395170
reach
"Overexpression of CSN6 reduced the protein levels of Fbxw7alpha and increased Myc protein levels; while CSN6 knockdown by shRNA resulted in increased protein levels of Fbxw7alpha and decreased protein levels of Myc in two cell lines HCT116 and U2OS cells (XREF_FIG)."
25395170