IndraLab

Statements

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"For example, the poxviral E3L protein, a known PKR and dsRNA antagonist, has recently been shown to inhibit IRF3 activation in a PKR-independent manner ( Xiang et al., 2002 )."
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"For immunology, dsRNA containing multiple groups of I/U inhibits the activity of MDA5, RIG1 and IRF-3, thus inhibiting the induction pathway of IFN-I and affecting the host antiviral response (5, 28) (Figure 4)."
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"Furthermore, in cells exposed to poly I:C, short dsRNA of 20 base-pairs containing inosine-uridine pairs bound to RIG-I and MDA-5 inhibit the downstream activation of IRF-3, and consequently the induc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recent studies have demonstrated that NS3/4a blocks the dsRNA-induced activation of IRF3 ( Foy et al., 2003; Li et al., 2005; Foy et al., 2005 ), a critical component of the type 1 IFN response pathwa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been hypothesized that the NS1 protein may bind to double strand RNA (dsRNA) produced during viral infection thereby preventing activation of NF-κB, IRF3, and IRF7 and resulting in the inhibiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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