IndraLab

Statements


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"Seventh, alcohol induced dramatic reduction of USP2, the major deubiquitinating enzyme may provide mechanistic perspectives underlying caveolar protein depletion and/or degradation as USP2 depletion has been documented to significantly enhance protein degradation."

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"Knockdown of USP2 or USP14 accelerated protein degradation of TNF-alpha, and abolished the effect of miR-124 on TNF-alpha protein stability."

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"The ubiquitin dependent proteolysis of cyclin D1 is antagonized by the deubiquitinating enzyme USP2, thus increasing cyclin D1 half-life."