IndraLab

Statements

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"However, these data are contradicted by recent findings showing that USP20 promotes proliferation, invasion, migration, and chemoresistance of multiple cancer cells via deubiquitylation of β-catenin [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"67 A recent study reported that USP20 stabilizes β‐catenin and activates Wnt/β‐catenin signaling pathway, thereby promoting the migration, invasion, and proliferation of cancer cells."
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"And they also observed that USP20 overexpression markedly increased cell proliferation, migration and invasion in these cancer cell lines."
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"The results showed that overexpression of USP20 significantly enhanced SW480 cell migration and invasion ( Figures 8D–G )."
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"Transwell results showed that knockdown of USP20 significantly decreased SW480 cell migration and invasion ( Figures 8K–N )."
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"Li et al. first identified SNAI2 as one substrate of USP20, they found that USP20 can increase the stability of SNAI2, and subsequently increase the migration and invasion of ER breast cancer cell lines [67]."
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"Another DUB, USP20, promoted transwell migration and invasion through the deubiquitination of SNAIL family transcriptional repressor 2 (SNAI2)."
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