IndraLab

Statements

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"Additionally, the suppression of STAMBPL1 inhibits tumor growth and the proliferation in colorectal and gastric cancer cells [20,21]."
37511599
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"These findings highlight the diverse roles that deubiquitinases play in HCC, either by promoting or suppressing the disease, and suggest that they could be potential targets for therapeutic intervention in HCC.In the study, we identified one oncogene gene (STAMBPL1) which promote the proliferation and metastasis of HCC."
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"Functionally, STAMBPL1 notably enhances CCA cell proliferation and metastasis while impeding ferroptosis."
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"Knockdown of STAMBPL1 reduced cell viability of CRC and suppressed the proliferation, invasion, and migration."
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"CCK-8 assays revealed that the inhibition of STAMBPL1 could reduce the proliferation of HCCLM3 and Hep3B (Fig. 3G)."
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"STAMBPL1 has been reported to promote cell proliferation and function as an oncogenic protein in gastric cancer ( Yu et al., 2019 )."
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"Following STAMBPL1 knockdown by short hairpin RNA (sh)STAMBPL1, cell proliferation was significantly suppressed, the cell apoptosis rate was significantly upregulated, and the numbers of invasive AGS cells and the AGS wound healing rate were significantly decreased (P<0.01 and P<0.001, respectively), compared with those in the shControl group."
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"These results suggested that AGS cell proliferation was suppressed by STAMBPL1 knockdown."
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"STAMBPL1 promotes the ability of cell cloning and proliferation in LUAD."
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"Functionally, STAMBPL1 significantly promoted HCC cells proliferation and metastasis, and it interacts with TRAF2 and stabilize it via the deubiquitination at the K63 residue."
38419066