IndraLab

Statements

HpTx1 activates SCN11A. 3 / 3
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eidos
"HpTx1 inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8 ."
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eidos
"Taken together , these results suggested that HpTx1 enhances Nav1.9 activity by inhibiting its fast inactivation and that the mechanism by which HpTx1 improves membrane excitability and evokes pain in Nav1.7-KO mice might be related to this enhanced Nav1.9 activity ."
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"HpTx1 evoked robust pain responses and produced profound hypersensitivity to mechanical and thermal stimuli in Nav1.7-KO mice ( Fig.1c-e ) , as revealed by the depolarized RMP , reduced rheobase and increased AP firing in some small DRG neurons with Nav1.9 activation by HpTx1 ( Fig.2e-g ) ."
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