IndraLab

Statements


Mutated KRAS activates MAPK1. 2 / 2
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reach
"This evidence suggests that constitutive activation of MAPK1 synergistically induced by frequent mutation of KRAS2 and the loss of function of DUSP6 plays key roles in pancreatic carcinogenesis and progression."

reach
"In our study, we demonstrated that up-regulation of E-cadherin by AKR1B10 knocked down or inhibition in CD18 pancreatic carcinoma cells appeared via down-regulation of mutant Kras activated ERK2, Akt and Ikk-alpha and NF-kappaB signaling, which was parallel with the effect of siRNA-knockdown K-Ras in CD18 pancreatic carcinoma cells."