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"In our study, we demonstrated that up-regulation of E-cadherin by AKR1B10 knocked down or inhibition in CD18 pancreatic carcinoma cells appeared via down-regulation of mutant Kras activated ERK2, Akt and Ikk-alpha and NF-kappaB signaling, which was parallel with the effect of siRNA-knockdown K-Ras in CD18 pancreatic carcinoma cells."